Chiral gold(III) complexes: speciation, in vitro, and in vivo anticancer profile
CHEMICAL COMMUNICATIONS(2022)
Abstract
Emerging synthetic development of chiral gold(III) complexes has prompted new opportunities in catalysis and material science with limited utility in biomedicine. Here, we demonstrate potential chemotherapeutic capability of [C<^>N]Au(III)Cl(R-DuPhos) (1-7) complexes, containing 1,2-bis[(2R,5R)-2,5-dialkylphospholano]benzene, which shows good stabilty, potent anticancer activity, and tolerability in mice.
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Key words
complexes,speciation,gold<scp>iii</scp>
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