Dominant Negative TRAF3 Variant With Recurrent Mycobacterium abscessus Infection and Bronchiectasis

Mei Fong Liew,Hui Fang Lim,Mui Cheng Liang, Ives Lim,Zhaohong Tan, Rachel Ying Min Tan,Qi Hui Sam,Win Mar Soe,Sen Hee Tay,Shengli Xu,Matthew Wook Chang,Roger Foo,Tuck Wah Soong,Sharada Ravikumar,Louis Yi Ann Chai

OPEN FORUM INFECTIOUS DISEASES（2022）

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摘要

Host factors leading to pulmonary nontuberculous mycobacteria (PNTM) disease are poorly understood compared with disseminated NTM disease, which is linked to the interleukin 12-interferon gamma signaling pathway. We investigated the tumor necrosis factor receptor associated factor 3 (TRAF3) R338W variant in a patient with recurrent PNTM infection, demonstrating TRAF3- and TNF-alpha-deficient phenotypes via ex vivo immune and cloning-transfection cellular studies.

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关键词

immunocompromised host, nontuberculous mycobacteria, pulmonary infection, transfection

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