HHLA2 predicts improved prognosis of anti-PD-1/PD-L1 immunotherapy in patients with melanoma.

Fu-Xue Huang, Jun-Wan Wu,Xia-Qin Cheng,Jiu-Hong Wang,Xi-Zhi Wen,Jing-Jing Li, Qiong Zhang,Hang Jiang,Qiu-Yue Ding,Xiao-Feng Zhu,Xiao-Shi Zhang,Ya Ding,Dan-Dan Li

Frontiers in immunology（2022）

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摘要

Our findings revealed that high expression of HHLA2 has important values in predicting the response to ICB and indicating improved PFS and OS in patients with advanced and unresectable melanoma, suggesting that HHLA2 may serve as a costimulatory ligand in melanoma, which renders it as an ideal biomarker for immunotherapy.

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HHLA2,immunotherapy,melanoma,prognosis,tumor infiltrating lymphocytes

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