Loss of VOPP1 Contributes to BET Inhibitor Acquired Resistance in Non-Small Cell Lung Cancer Cells.

Lin Sun,Qian Wu,Xia-Juan Huan,Chang-Qing Tian,Ying-Qing Wang,Ze-Hong Miao

Molecular cancer research : MCR（2022）

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摘要

Based on these results, for the first time, we establish a causal link from VOPP1 loss to BCL-2 gain and then to BETi resistance, which provides new insights into BETi resistance and paves the way for further testing to circumvent BETi resistance.

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关键词

bet inhibitor acquired resistance,vopp1 contributes,cell lung cancer,non–small cell lung cancer,lung cancer

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