Cryo-Electron Microscopy Reveals Cardiac Myosin Binding Protein-C M-Domain Interactions with the Thin Filament

Cristina Risi, Edwin Villanueva,Betty Belknap,Rachel L. Sadler,Samantha P. Harris,Howard H. White,Vitold E. Galkin

SSRN Electronic Journal（2022）

引用 3|浏览6

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摘要

•N-terminal domains (C0, C1, M and C2) of cMyBP-C together activate the cardiac TF.•The M-domain interacts with actin via helix 3 of its tri-helix bundle (THB) region.•Positions of C0, C1, M and C2 on cardiac TF lead to a model of TF activation.

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关键词

cardiac myosin binding protein C,cardiac muscle regulation,thin filament,cryo electron microscopy,actin binding proteins

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