Facile fabrication of biomimetic silicified gelatin scaffolds for angiogenesis and bone regeneration by a bioinspired polymer-induced liquid precursor
Materials & Design(2022)
Abstract
•A biomimetic strategy is presented to fabricate highly bioactive hybrid nanocomposite scaffolds via vacuum impregnation and in situ free radial polymerization.•The resulting biohybrid scaffold possessed not only a multilevel structure in the nano (nanoparticles)-micro (open pores)-macro (scaffold) but also satisfactory physicochemical properties, which was beneficial to bone regeneration.•The resulting biohybrid scaffold significantly promoted cell behaviors, including cell adhesion, proliferation, spreading, and differentiation during osteogenesis and angiogenesis.•The biohybrid nanocomposites with a robust ability to facilitate new bone formation and vascularization offer a promising alternative as bone substitutes for vascularized bone regeneration.
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Key words
Bioinspired materials,Osteogenesis,Biomineralization,Angiogenesis,Bone regeneration,Polymer-induced liquid precursor
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