Autophagy guided interventions to modify the cardiac phenotype of Danon disease

Dor Yadin, Zachary Petrover,Asher Shainberg,Ronny Alcalai,Maayan Waldman,Jon Seidman,Christine E. Seidman,Nader G. Abraham,Edith Hochhauser,Michael Arad

Biochemical Pharmacology（2022）

引用 6|浏览10

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摘要

Lamp2 controls autophagy through autolysosome formation. Lamp2 mutations lead to accumulation of undegraded cellular debris. Autophagy may be modified by physiological/drugs stimuli. These interventions affect the phenotype of Danon's cardiomyopathy.

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关键词

Cardiomyopathy,LAMP2,Autophagy,Proteasome,Diet,Animal model of human disease

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