Comparison of tissue distribution of free and protein bound Nɛ-carboxymethyllysine after long-term oral administration to mice

Xiaojin Yuan, Yating Bai,Jing Zhang,Ruohan Zhai,Chenxi Nie,Aobai Tu, Suchen Li,Zhifei Chen,Min Zhang,Juxiu Li

Food Research International（2022）

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摘要

•Dietary bound CML was more likely to accumulate in tissues and organs than free CML.•Colon was the main tissue for the accumulation of free and total CML.•Accumulation of free CML in tissues was significantly correlated with serum free CML.

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关键词

Advanced glycation end products,Nε-carboxymethyllysine,Uptake,Accumulation,Fecal excretion,High-performance liquid chromatography-tandem mass spectrometry

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