GnRH agonist administration as luteal support on the transfer day of single blastocyst in dual-triggered cycles

Ginekologia polska(2022)

Cited 0|Views5
No score
Abstract
Objectives: Luteal phase support with gonadotropin-releasing hormone agonist (GnRH-a) has been considered in terms of its potential beneficial effects on in vitro fertilisation (IVF) cycles. In our study, we assessed the effectiveness of single-dose GnRH-a administration in dual-triggered cycles on pregnancy outcomes.Material and methods: Eighty women who underwent intra cytoplasmic sperm injection (ICSI) cycle and had fresh blastocyst transfer were divided into two groups in terms of luteal phase support. The study group (Group A) consisted of patients (n = 40) who received a single-dose GnRH-a injection (0.1 mg of triptorelin acetate) subcutaneously 6 days after oocyte retrieval in addition to 600 mg daily of micronised progesterone, and the control group (Group B) comprised of patients (n = 40) taking 600 mg micronised progesterone daily from the first day after oocyte retrieval. GnRH-a and hu-man chorionic gonadotropin (hCG; dual trigger) were administered to all patients. Comparison of the clinical pregnancy and live birth rates was our main goal.Results: There was no significant difference between the two groups in terms of beta-hCG positivity rates, clinical pregnancy rates and live birth rates (p-value for beta-hCG = 0.25, clinical pregnancy = 0.80, live birth = 0.45).Conclusions: Our study demonstrated that in dual triggered cycles administration of a single dose of GnRH-a on the trans-fer day of a single blastocyst in addition to routine luteal phase support with progesterone does not statistically increase implantation, clinical pregnancy or live birth rates.
More
Translated text
Key words
GnRH agonist,IVF,luteal phase support
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined