Unblinding the watchmaker: cancer treatment and drug design in the face of evolutionary pressure.
Expert opinion on drug discovery(2022)
摘要
Reevaluating emerging therapy resistance in tumors as an evolutionary mechanism to survive in a rapidly and drastically altering fitness landscape leads to novel treatment strategies and distinct requirements for new drugs. Here, we propose a scheme of considerations that need to be applied prior to the discovery of novel therapeutic drugs.
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关键词
Cancer,dynamic treatment,fitness landscape steering,mutational escape
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