BMMSC-derived exosomes attenuate cardiopulmonary bypass-related acute lung injury by reducing inflammatory response and oxidative stress.

Tao-Yuan Zhang,Hui Zhang,Jing-Yu Deng,Hai-Rong Gong,Yun Yan,Zheng Zhang,Chong Lei

Current stem cell research & therapy（2022）

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摘要

In summary, we indicate that BMMSC-Exo reduces CPB-related ALI by alleviating inflammation and oxidative stress. The underlying mechanism may involve the NF-κB p65 and Akt/Nrf2/HO-1 signaling pathways.

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关键词

Acute lung injury,Bone marrow mesenchymal stem cells,Cardiopulmonary bypass,Exosomes,Inflammation,Oxidative stress

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