Laminin α5_CD239_Spectrin is a candidate association that compensates the linkage between the basement membrane and cytoskeleton in skeletal muscle fibers

Yamato Kikkawa,Masumi Matsunuma,Ryuji Kan,Yuji Yamada,Keisuke Hamada,Motoyoshi Nomizu,Yoichi Negishi,Shushi Nagamori,Tatsushi Toda,Minoru Tanaka,Motoi Kanagawa

Matrix Biology Plus（2022）

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摘要

•Laminin α5_CD239_spectrin complex is a candidate linkage in sarcolemma.•The linkage molecules are expressed in embryonic and regenerative muscle fibers.•CD239 expression is upregulated by steroid therapy for muscular dystrophy.•The compensatory linkage may be a therapeutic target for muscular dystrophy.

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关键词

Basement membrane,Laminin,CD239,BCAM,Spectrin,Muscular dystrophy

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