Disruption of Nuclear Envelope Integrity As a Possible Initiating Event in Tauopathies

Marine Prissette,Wen Fury,Matthew Koss,Claudia Racioppi, Daria Fedorova, Ella Dragileva,Georgia Clarke, Taylor Pohl,John Dugan, Diana Ahrens,Joyce Chiu,Charleen Hunt,Chia-Jen Siao,Tara Young, Arijit Bhowmick, Vitaliy Rogulin,Mathieu Desclaux,Eric Y. Hayden,Michael Podgorski, Min Gao,Lynn E. Macdonald,David Frendewey,George D. Yancopoulos,Brian Zambrowicz

Cell Reports（2022）

Cited 25|Views20

Key words

microtubule associate protein tau,tau phosphorylation,tau aggregation,tauopathy,CRISPR genetic screen,neurodegeneration,ASO,nuclear envelope rupture,nuclear envelope integrity,LEM domain proteins

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