Size-dependent placental retention effect of liposomes in ICR pregnant mice: Potential superiority in placenta-derived disease therapy
International Journal of Pharmaceutics(2022)
Abstract
This study explored the size-dependent placental retention effect of liposomes in ICR pregnant mice for placenta-derived disease drug delivery. The results showed that the 500 nm-sized liposomes had the highest P/F value (the ratio of fluorescence in placenta and fetus sections) and thus exhibited the strongest placental retention effect and the weakest placental penetration ability.
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Key words
Placenta,Liposome,Different particle size,Retention effect,Pregnant mice
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