Sphingosine-1-phosphate Attenuates Endoplasmic Reticulum Stress-induced Cardiomyocyte Apoptosis Through Sphingosine-1-phosphate Receptor 1.

Kengquan Chen,Zhongqin Wang, Chao Liu, Xing Yang,Jiangang Jiang

Archives of medical research（2022）

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摘要

This study is the first to demonstrate that S1P relieves ER stress-induced myocardial apoptosis via S1PR1/AKT and S1PR1/ERK1/2, which are potential therapeutic targets for heart disease.

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关键词

Endoplasmic reticulum stress,Heart disease treatment,Myocardial apoptosis,Sphingosine-1-phosphate,Therapeutic target

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