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DDX58 Is Associated With Susceptibility to Severe Influenza Virus Infection in Children and Adolescents.

Sanghun Lee,Yu Zhang,Margaret Newhams,Tanya Novak,Paul G Thomas,Peter M Mourani,Mark W Hall,Laura L Loftis,Natalie Z Cvijanovich,Keiko M Tarquinio,Adam J Schwarz, Scott L Weiss,Neal J Thomas,Barry Markovitz,Melissa L Cullimore,Ronald C Sanders,Matt S Zinter,Janice E Sullivan,Natasha B Halasa,Melania M Bembea,John S Giuliano,Katri V Typpo,Ryan A Nofziger,Steven L Shein,Michele Kong,Bria M Coates,Scott T Weiss,Christoph Lange,Helen C Su,Adrienne G Randolph

The Journal of infectious diseases（2022）

Cited 2|Views21
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Abstract
We provide evidence associating common gene variants in DDX58 with susceptibility to severe influenza infection in children. RIG-I may be essential for preventing life-threatening influenza-associated disease.
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Key words
DDX58,RIG-I receptor,host genetics,pediatric influenza,susceptibility
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