Eosinophil-derived interferon-γ drives transmembrane protein 119-induced new bone formation in chronic rhinosinusitis with nasal polyps.

Sungsin Jo, Bong Joon Jin,Seung Hoon Lee,Hye-Ryeong Jo, Joo Mi Park,Kyung-Gyun Hwang,Mina Rho,Tae-Hwan Kim,Seok Hyun Cho

International forum of allergy & rhinology（2023）

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摘要

Eosinophil-derived IFN-γ promotes the bone-forming activities of sinus bone cells via the STAT1-TMEM119 signaling pathway. Interleukin-4-eosinophil-IFN-γ axis may be crucial for TMEM119-mediated new bone formation in CRSwNP.

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关键词

CRSwNP,TMEM119,eosinophil-derived IFN-γ,new bone formation,sinus bone cells

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