Viral Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Omicron Infection in mRNA-Vaccinated Individuals Treated and Not Treated with Nirmatrelvir-Ritonavir.

Eric Y Dai, Kannon A Lee, Audrey B Nathanson, Ariana T Leonelli,Brittany A Petros,Taylor Brock-Fisher,Sabrina T Dobbins,Bronwyn L MacInnis, Amelia Capone,Nancy Littlehale,Julie Boucau,Caitlin Marino,Amy K Barczak,Pardis C Sabeti,Michael Springer,Kathryn E Stephenson

medRxiv : the preprint server for health sciences（2022）

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摘要

We measured viral kinetics of SARS-CoV-2 Omicron infection in 36 mRNA-vaccinated individuals, 11 of whom were treated with nirmatrelvir-ritonavir (NMV-r). We found that NMV-r was associated with greater incidence of viral rebound compared to no treatment. For those that did not rebound, NMV-r significantly reduced time to PCR conversion.

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关键词

COVID-19,Paxlovid,SARS-CoV-2,nirmatrelvir,viral rebound

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