Deep learning-based 4D-synthetic CTs from sparse-view CBCTs for dose calculations in adaptive proton therapy.

Adrian Thummerer,Carmen Seller Oria,Paolo Zaffino,Sabine Visser,Arturs Meijers,Gabriel Guterres Marmitt,Robin Wijsman,Joao Seco,Johannes Albertus Langendijk,Antje Christin Knopf,Maria Francesca Spadea,Stefan Both

Medical physics（2022）

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摘要

In this study, we have investigated the accuracy of deep learning-based 4D-sCTs for daily dose calculations in adaptive proton therapy. Despite image quality differences between 4D-sCTs and 3D-sCTs, comparable dosimetric accuracy was observed globally and locally. Further improvement of 3D and 4D lung sCTs could be achieved by increasing CT number accuracy in lung tissues.

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关键词

4D imaging,adaptive proton therapy,deep learning,synthetic CT

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