Contribution of the Opioid System to the Antidepressant Effects of Fluoxetine.

Elena Carazo-Arias,Phi T Nguyen,Marley Kass,Hyun Jung Jee,Katherine M Nautiyal,Valerie Magalong, Lilian Coie,Valentine Andreu,Mark M Gergues,Huzefa Khalil,Huda Akil,Danusa Mar Arcego,Michael Meaney,Christoph Anacker,Benjamin A Samuels,John E Pintar,Irina Morozova,Sergey Kalachikov,Rene Hen

Biological psychiatry（2022）

引用 6|浏览14

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摘要

These data indicate that the opioid system is involved in the antidepressant effects of fluoxetine, and this effect may be mediated through the upregulation of proenkephalin in a subpopulation of mature granule cells.

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关键词

Dentate gyrus,Depression,Enkephalin,Fluoxetine,Opioid,Selective serotonin reuptake inhibitors (SSRI)

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