Synthesized HMGB1 peptide prevents the progression of inflammation, steatosis, fibrosis, and tumor occurrence in a non-alcoholic steatohepatitis mouse model.

Yui Ishii,Atsunori Tsuchiya,Kazuki Natsui,Youhei Koseki,Nobutaka Takeda,Kei Tomiyoshi,Fusako Yamazaki,Yuki Yoshida,Takashi Shimbo,Katsuto Tamai,Shuji Terai

Hepatology research : the official journal of the Japan Society of Hepatology（2022）

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摘要

This HMGB1 peptide can reduce liver damage, improve fibrosis and steatosis, and inhibit carcinogenesis, suggesting that the peptide would be a new treatment candidate for NASH and can contribute to the long-term prognosis for patients with NASH.

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关键词

HMGB1,fibrosis,inflammation,liver,non-alcoholic steatohepatitis,peptide,tumor

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