Eupalinolide B attenuates lipopolysaccharide-induced acute lung injury through inhibition of NF-κB and MAPKs signaling by targeting TAK1 protein

Luyao Yang,Hongqing Chen,Qiongying Hu,Lu Liu,Yun Yuan,Chuantao Zhang,Jianyuan Tang,Xiaofei Shen

International Immunopharmacology（2022）

引用 4|浏览11

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摘要

•Eupalinolide B (EB) inhibit LPS-induced acute lung injury in mice.•EB directly binds to TAK1, and inhibits NF-κB and MAPKs activation.•The α,γ-unsaturated lactone of EB is vital for its anti-inflammatory effect.

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关键词

Eupalinolide B,Acute lung injury,Lipopolysaccharide,TAK1,NF-κB and MAPKs,Macrophages

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