Neural Net Modeling of Checkpoint Inhibitor Related Myocarditis and Steroid Response.

Filip Stefanovic,Andres Gomez-Caminero,David M Jacobs,Poornima Subramanian,Igor Puzanov,Maya R Chilbert,Steven G Feuerstein,Yan Yatsynovich,Benjamin Switzer,Jerome J Schentag

Clinical pharmacology : advances and applications（2022）

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摘要

Our study shows that a supervised learning NN can be used to model rare events such as ICI-related myocarditis and thus provide clinical insight into drivers of progression and treatment outcomes. These findings direct attention to early detection biomarkers and clinical symptoms as the best means of implementing early and potentially life-saving steroid treatment.

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关键词

NN modeling,checkpoint inhibitor,dose and timing,myocarditis,steroid response

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