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A novel dibenzofuran from endophytic fungus Mycosphaerella nawae preferentially inhibits CD4 + T cell activation and proliferation.

Li-Wei Wang, Jie Li, Le-Xin Gao,Feng-Yang Chen

Journal of applied microbiology（2022）

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Abstract
This work obtained iME, a new dibenzofuran derived from endophytic fungus. iME has the capacity to inhibit CD4 T-cell activation and therefore is a novel potential immunosuppressant for development in the future.
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Key words
Mycosphaerella nawae ,(+)-isomycousunine enamine,CD4+ T cell,dibenzofura,endophytic fungus,immunosuppressant
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