Receptor-ligand affinity-based screening and isolation of water-soluble 5-lipoxygenase inhibitors from Phellinus igniarius

Ruoyao Liu,Yuchi Zhang,Sainan Li,Chunming Liu,Siyuan Zhuang,Xu Zhou,Yanjie Li,Jiaqi Liang

Journal of Chromatography B（2022）

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摘要

•1. Water extraction and alcohol precipitation yielded Phellinus igniarius extracts.•2. Dual probing of compound activity by UF-LC combined with molecular docking.•3. Aqueous extraction was optimized using the response surface methodology.•4. Target compounds were isolated using HSCCC combined with semi-preparative LC.•5. Purity of all three target compounds exceeded 98%.

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关键词

Phellinus igniarius,Response surface methodology,Ultrafiltration,Combination chromatography,5-lipoxygenase

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