Comprehensive characterization of immune landscape of Indian and Western triple negative breast cancers (vol 25, 101511, 2022)

•By comprehensively profiling the immune transcriptome of triple-negative breast cancers (TNBCs) and applying machine learning methods, we identified three immunotypes (1, 2 and 3) with significant differences in prognosis and therapy responses.•TNBC is much more common in India than in the West. However, there was no significant difference in immune transcriptome between Indian and Western TNBCs in our study.•Our analysis shows biological, signaling and clinical features of three TNBC immunotypes.•Immunotype-1 gene signature is associated with improved prognosis and treatment responses in a cross-cancer comparison analysis of melanoma patients treated with anti-PDL1 therapy.•Our study identified a potential opportunity to stratify patients for MAGEA3 and anti-PDL1-based therapies, which warrants further validation.