Long-term antiretroviral therapy mitigates mortality and morbidity independent of HIV tropism: 18 years follow-up in a women's cohort.

Barbara Weiser,Binshan Shi,Kimdar Kemal,Harold Burger,Howard Minkoff,Qiuhu Shi,Wei Gao,Esther Robison,Susan Holman,Tamara Schroeder, Alissa Gormley,Kathryn Anastos,Christina Ramirez

AIDS (London, England)（2022）

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摘要

Long-term cART markedly mitigated the deleterious effect of X4 viruses on AIDS morbidity and mortality. Mitigation was correlated with duration of viral suppression, supporting HIV-1 suppression as a crucial goal.

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关键词

cART, CCR5, combination antiretroviral therapy, CXCR4, HAART, HIV infection in women, HIV-1, HIV-1 coreceptor usage, HIV-1 tropism, immunologic nonresponders

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