cccDNA surrogate MC-HBV-based screen identifies cohesin complex as a novel HBV restriction factor.

Cellular and molecular gastroenterology and hepatology（2022）

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摘要

Our data not only provide a feasible approach to explore cccDNA-binding factors but also identify cohesin/CTCF complex as a critical host restriction factor for cccDNA-driven HBV replication. These findings provide a novel insight into cccDNA-host interaction and targeted therapeutic intervention for HBV infection.

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关键词

Cohesin,HBx,SMC3,cccDNA

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