Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation
The Journal of allergy and clinical immunology（2023）
摘要
Recipients of unconditioned HCT for SCID may develop late post-HCT T-cell exhaustion as a result of diminished production of T-lineage cells. Elevated expression of inhibitory receptors on their T cells may be a biomarker of poor long-term T-cell reconstitution.
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关键词
Conditioning chemotherapy,hematopoietic cell transplantation (HCT),immune reconstitution,severe combined immunodeficiency (SCID),T-cell exhaustion
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