Microbiological substantiation of the use of xenografts saturated with silver nanocrystals for the treatment of burn wounds

The aim of the work: to study the antimicrobial efficacy of xenografts saturated by silver nanoparticles, to suggest their application in the treatment of burned wounds. Materials and Methods. The antimicrobial efficacy of xenografts saturated with silver nanocrystals was investigated in vitro by diffusion into agar, in a liquid nutrient medium and by studying the adhesive activity using test cultures: Staphylococcus aureus АТСС 6538, Escherichia coli АТСС 25922, Pseudomonas aeruginosa АТСС 9027 and Candida albicans АТСС 885-653. Results and Discussion. The antimicrobial properties of silver, which was saturated the pieces of cryolyophilized xenoskin, were not inferior to the effectiveness of modern dressings, which were used as a positive control (wound dressing applications Mepilex Transfer Ag (Mölnlycke, Sweden) та Atrauman Ag (Heidenheim, Germany)) in studies. Nanosilver had reduced a bioburden in infected wounds and the adhesive potential of microorganisms, which is important to prevent contamination of burn wounds. Thus, the possibility of using xenografts saturated with silver nanocrystals it is considered for local treatment of burns in order to prevent purulent-inflammatory complications that may occur.