The impacts of the "4+7" pilot policy on the volume, expenditures, and daily cost of Serotonin-Specific Reuptake Inhibitors (SSRIs) antidepressants: A quasi-experimental study
FRONTIERS IN PHARMACOLOGY(2022)
Abstract
Objectives: The purpose of this study was to quantitatively evaluate the impacts of the "4 + 7 " pilot policy on purchase volume, purchase expenditures, and daily cost and to find the changes in the use of SSRIs.Methods: Data was collected covering 31 months, before, during, and after the "4 + 7 " pilot policy was implemented in Shenzhen. Interrupted time-series (ITS) analysis was used to examine whether there had been a significant effect with the onset of the "4 + 7 " pilot policy in March 2019.Findings: The daily cost of policy-related drugs had a substantial drop of 2.93 yuan under the "4 + 7 " pilot policy. The result has shown a 76.70% increase in volume and a 3.39% decrease in the expenditure on policy-related drugs. This study found that the "4 + 7 " pilot policy increased the proportion of purchasing winning drugs, with an increment of 85.60 percent. After the implementation of the "4 + 7 " pilot policy, policy-related drugs decreased by 443.55thousand Chinese yuan. The study indicated that volume of winning products significantly increased as shown in the regression with a level coefficient (beta ( 2 )) of -224.17 (p < 0.001) and trend coefficient (beta ( 3 )) of 15.74 (p < 0.001). The result revealed that both volume and expenditures on branded products showed a significant decrease in the regression in the post-intervention period (level coefficient of volume: beta ( 2 ) = -57.65, p < 0.01, trend coefficient of volume: beta ( 3 ) = -3.44, p < 0.01; level coefficient of expenditure: beta ( 2 ) = -712.98, p < 0.01, trend coefficient of expenditure: beta ( 3 ) = -40.10, p < 0.01). Conclusion: The volume-based procurement has successfully led to price reductions and improved the affordability of medicines, especially for those with chronic diseases. The volume-based procurement has demonstrated initial success in reshaping the composition of the Chinese pharmaceutical market in favor of generics with high quality and low prices.
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Key words
the"4+7" pilot policy,volume-based procurement,price,expenditures,serotonin- antidepressants,interrupted time-series analysis,(ITSA),quasi-experimental design and analysis
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