Efficient access to domain-integrated estradiol-flavone hybrids via the corresponding chalcones and their in vitro anticancer potential

Barnabás Molnár,Mohana K Gopisetty,Ferenc István Nagy,Dóra Izabella Adamecz,Zsolt Kása,Mónika Kiricsi,Éva Frank

Steroids（2022）

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摘要

•Novel estradiol-chalcone and estradiol-flavone hybrids were synthesized.•Framework integration was achieved via molecular hybridization.•Pharmalogical screening was carried out to determine their antiproliferative activity.•Compounds 3c, 3d and 3e exhibit prominent cytotoxic activity on cancerous cell lines.

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关键词

Steroid,Molecular hybridization,Chalcone,Flavone,Antiproliferative activity

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