Inosine‐Based Supramolecular Hydrogel for Highly Efficient PD‐L1 Blockade Therapy via Mediating CD8 ⁺ T Cells (Adv. Funct. Mater. 33/2022)

Tumor Immunotherapeutic Gels In article number 2204273, Dunfang Zhang, Hang Zhao, and co-workers demonstrate that an inosine-based supramolecular hydrogel, IPBisoG, can achieve the gradual and sequential release of inosine and aPDL1. Inosine, which enhancs the proliferation and function of CD8+ T cells, together with aPDL1, the blocker of the immunosuppressive pathway in the tumor microenvironment, could highly enhance the in vivo efficacy of PD-L1 blockade therapy.