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Association of an IFN-γ variant with susceptibility to chronic hepatitis B by the enhancement of HBV DNA replication

Walid Ben Selma,Ahmed Baligh Laribi,Sana Alibi,Jalel Boukadida

Cytokine（2021）

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Abstract
Interferon gamma (IFN-γ) is a crucial cytokine in host immune response to hepatitis B virus (HBV) infection. This study aimed to determine whether a functional polymorphism +874T/A in IFN-γ gene linked to high and low producer phenotypes [IFN-γ (+874Thigh → Alow)] may alter the outcomes of chronic HBV infection in Tunisian population.
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Key words
HBV,Hepatitis,IFN-γ,Polymorphism,Susceptibility
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