Interrupting specific hydrogen bonds between ELF3 and MED23 as an alternative drug resistance-free strategy for HER2-overexpressing cancers.

Soo-Yeon Hwang,Seojeong Park,Hyunji Jo,Seung Hee Seo,Kyung-Hwa Jeon,Seojeong Kim,Ah-Reum Jung,Chanju Song,Misun Ahn,Soo Yeon Kwak,Hwa-Jong Lee,Motonari Uesugi,Younghwa Na,Youngjoo Kwon

Journal of advanced research（2022）

引用 1|浏览10

暂无评分

摘要

Our approach to develop specific ELF3-MED23 PPI inhibitor without interfering other PPIs of MED23 can finally lead to successful development of a drug resistance-free compound to interrogate HER2 biology in diverse conditions of cancers overexpressing HER2.

查看译文

关键词

ELF3-MED23 interaction,HER2 transcriptional downregulator,Hotspot identification,Small molecule PPI inhibitor,Trastuzumab resistance

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要