The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2

Andrey A Ivashchenko,Bogdan A Zagribelnyy,Yan A Ivanenkov, Ilya A Ivashchenko,Ruben N Karapetian,Dmitry V Kravchenko,Nikolay P Savchuk,Elena V Yakubova,Alexandre V Ivachtchenko

MOLECULES（2022）

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Abstract

The efficacy of aprotinin combinations with selected antiviral-drugs treatment of influenza virus and coronavirus (SARS-CoV-2) infection was studied in mice models of influenza pneumonia and COVID-19. The high efficacy of the combinations in reducing virus titer in lungs and body weight loss and in increasing the survival rate were demonstrated. This preclinical study can be considered a confirmatory step before introducing the combinations into clinical assessment.

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Key words

aprotinin, antiviral drugs, SARS-CoV-2, COVID-19, influenza

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