Transforming growth factor-β receptor 1: An intervention target for genetic poor cartilage quality induced by prenatal dexamethasone exposure

•We confirmed that prenatal dexamethasone exposure leads to hereditary low cartilage quality;•Genetic low cartilage quality induced by dexamethasone exposure during pregnancy is associated with reduced cartilage matrix synthesis mediated by the inhibition of expression of the TGFβ signaling pathway;•Glucosamine can improve the hereditary low quality of cartilage caused by dexamethasone during pregnancy;•Glucosamine could reverse the poor genetic cartilage quality in offspring induced by PDE via up-regulating SP1 expression and promoting its binding to TGFβR1 promoter.