Zanubrutinib ameliorates lipopolysaccharide-induced acute lung injury via regulating macrophage polarization
International Immunopharmacology(2022)
Abstract
•Zanubrutinib could relieve LPS induced lung injuriesin mice.•JAK2/ STAT1 and TLR4/MyD88/NF-κB pathway is involved in Zanubrutinib -mediated M1 macrophage polarization in RAW264.7 cells.•Zanubrutinib promotes M2 macrophage activation through regulating JAK/STAT6 and PI3K /AKT pathway in RAW264.7 cells.
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Key words
Zanubrutinib,Acute lung injury,Macrophage polarization
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