Zanubrutinib ameliorates lipopolysaccharide-induced acute lung injury via regulating macrophage polarization

Xiaohe Li,Yuli Wei,Shimeng Li,Jingjing Liang,Zhichao Liu,Yunyao Cui,Jingjing Gao,Zhongyi Yang,Lei Li,Honggang Zhou,Shanshan Chen,Cheng Yang

International Immunopharmacology（2022）

Cited 7|Views8

No score

Abstract

•Zanubrutinib could relieve LPS induced lung injuriesin mice.•JAK2/ STAT1 and TLR4/MyD88/NF-κB pathway is involved in Zanubrutinib -mediated M1 macrophage polarization in RAW264.7 cells.•Zanubrutinib promotes M2 macrophage activation through regulating JAK/STAT6 and PI3K /AKT pathway in RAW264.7 cells.

Translated text

Key words

Zanubrutinib,Acute lung injury,Macrophage polarization

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined