Dual-jet electrospun PDLGA/PCU nonwovens as promising mesh implant materials with controlled release of sirolimus and diclofenac

Jakub Wlodarczyk,Monika Musial-Kulik,Katarzyna Jelonek,Mateusz Stojko,Paulina Karpeta-Jarzabek,Malgorzata Pastusiak,Henryk Janeczek,Piotr Dobrzynski,Michal Sobota,Janusz Kasperczyk

International Journal of Pharmaceutics（2022）

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摘要

•The hydrophilicity of PCU nanofibers affects the rate of drugs release.•Burst release reduction and/or initial drug release inhibition may be obtained.•The presence of sirolimus slows the hydrolytic degradation of PDLGA fibers.•The presence of diclofenac sodium intensifies the surface erosion of PDLGA fibers.•Mechanical properties during the degradation depend on the amount of loaded drugs.

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关键词

Controlled drug delivery system,Sirolimus,Diclofenac sodium,Electrospinning,Nanofibers,Hydrolytic degradation,Mechanical strength

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