Effectiveness of a Patient Education Bundle on Venous Thromboembolism Prophylaxis Administration by Sex

Introduction: Venous thromboembolism (VTE) is a frequent cause of preventable harm among hospitalized patients. Many prescribed prophylaxis doses are not administered despite supporting evidence. We previously demonstrated a patient-centered education bundle improved VTE prophylaxis administration broadly; however, patient-specific factors driving nonadministration are unclear. We examine the effects of the education bundle on missed doses of VTE prophylaxis by sex. Methods: Weperformeda post-hocanalysis of anonrandomized controlled trial toevaluate the differences in missed doses by sex. Pre-intervention and intervention periods for patients admitted to 16 surgical andmedical floors between 10/2014-03/2015 (pre-intervention) and 04/ 2015-12/2015 (intervention) were compared. We examined the conditional odds of (1) overall missed doses, (2) missed doses due to patient refusal, and (3) missed doses for other reasons. Results: Overall, 16,865 patients were included (pre-intervention 6853, intervention 10,012), with 2350 male and 2460 female patients (intervention), and 6373 male and 5682 female patients (control). Anymissed dose significantly reduced on the intervention floors amongmale (odds ratioOR 0.55; 95% confidence interval CI, 0.44-0.70, P< 0.001) and female (OR 0.59; 95% CI, 0.47-0.73, P < 0.001) patients. Similar significant reductions ensued for missed doses due to patient refusal (P < 0.001). Overall, there were no sex-specific differences (P-interaction>0.05). Conclusions: Our intervention increased VTE prophylaxis administration for both female and male patients, driven by decreased patient refusal. Patient education should be applicable to a wide range of patient demographics representative of the target group. To improve future interventions, quality improvement efforts should be evaluated based on patient demographics and drivers of differences in care. (c) 2022 Elsevier Inc. All rights reserved.