Intracellular pyruvate levels positively correlate with cytokine production capacity in tolerant monocytes from patients with pneumonia

Natasja A. Otto,Joe M. Butler,Alex R. Schuurman,Xanthe Brands,Bastiaan W. Haak,Augustijn M. Klarenbeek,Michel van Weeghel,Riekelt H. Houtkooper,Marja E. Jakobs,Daniël R. Faber,Alex F. de Vos,W. Joost Wiersinga,Brendon P. Scicluna,Tom van der Poll

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease（2022）

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摘要

•Monocytes from CAP patients have a reduced cytokine production capacity as compared to non-infectious controls.•Intracellular levels of pyruvate and α-ketoglutarate are increased in monocytes from patients.•Transcriptional data suggests an increased glycolytic flux in monocytes from patients.•Intracellular pyruvate levels correlate with the cytokine production capacity of monocytes from CAP patients.

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关键词

Community-acquired pneumonia (CAP),Monocytes,Tolerance,Cytokine production,Pyruvate

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