The role of the hot foot gene in the fertility of The in vitro fertilization and embryonic development of young adult and old mice as a model for assisted reproductive technology

The hotfoot mutation first occurred in strain of mice C57BL/Ks in 1964. The homozygous (ho/ho) hotfoot mutation show a quick pattern motion that produces a progressive neuromuscular disability of the hind legs. The (ho/ho) is an autosomal recessive mutation affects fertility and neuromuscular system in mice.