Classic cardiovascular protective signaling in angiotensin ii-induced novel preeclampsia rat model

These results demonstrate that we have recapitulated the PE model of Ang II infusion in rats. The expression of nNOS was reduced, and the localization of nNOS in the trophoblast suggested a new functional remodeling in the fetal vasculature.In the placenta, decreased expression of AT2R and nNOS may be a novel mechanism of impaired fetal development.