Transcriptome analysis reveals distinct innate immunity and ribosomal response at early stage of AcMNPV infection in haemocyte of silkworm resistant and susceptible strains

We propose a schematic diagram for the early transcriptional responses between the susceptible and resistant silkworm strains after AcMNPV infection. In brief, when AcMNPV infect susceptible strains of silkworm, the inhibition of innate immunity and host translational machinery, as well as up-regulation of cytoskeleton, that these responses promote baculoviral BV transport and ingress into the nucleus, thus facilitating the replication of baculovirus. However, when AcMNPV infect resistant strains of silkworm, down-regulation of endocytosis and RNA transport weakened the ability of the baculoviral BV entry into the nucleus, while up-regulation of ribosomal proteins and energy metabolic to inhibit the replication of the virus.