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Rehmanniae Radix Preparata (RRP) improves pain sensitization and suppresses PI3K/Akt/TRPV1 signaling pathway in estrogen deficient rats

Qiangqiang Jia, Hao Zhang,Bingke Xia,Yage Liu,Xuan Dai,Tianyuan Liu,Shan Wang,Yueyi Zhang,Meixi Lu,Beibei Chen,Ruyuan Zhu,Sihua Gao,Dieter Bromme,Xinxiang Wang,Lili Wang,Dongwei Zhang

Journal of Functional Foods（2022）

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Abstract
•Rehmanniae Radix Preparata improves pain sensitization in estrogen deficient rats.•Rehmanniae Radix Preparata suppresses PI3K/Akt/TRPV1 signaling in estrogen deficient rats.•Rehmanniae Radix Preparata is to be a novel source of anti-pain drug candidates.
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Key words
Rehmanniae Radix Preparata,Estrogen-deficient rats,Pain sensitivity,PI3K/Akt/TRPV1,Bone quality
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