Silicones with different crosslinking patterns: Assessment from the perspective of their suitability for biomaterials

•Silicone films with different crosslinking patterns are prepared and bio-assessed.•The hydrolytic and the enzymatic stability depend on the crosslinking chemistry.•Adhesion work values indicate a lower risk for thrombosis in short-term applications.•Residual functional groups favor surface cell adhesion, bio- and mucoadhesion.•Biocidal activity strongly depends on the film`s crosslinking conditions.