Isoflavonoids modified with azole heterocycles with three heteroatoms

Heterocycle modified chromones are attracting increasing attention as novel potential therapeutic agents due to their effective bioactivities and low toxicity. This review describes all strategies and versatile synthons that have been developed to date for the synthesis of isoflavone heterocyclic analogs containing isolated 5-member heterocyclic rings with three different or identical heteroatoms. Their biological activity is also represented.