Three organotin(IV) Schiff-base carboxylates: Synthesis, structural characterization and in vitro cytotoxicity against cis-platin-resistent cancer cells
Journal of Molecular Structure(2022)
摘要
•Three organotin(IV) Schiff base carboxylates suppressing the growth of four cis-platin-resistent human lung and colon cancer cells were synthesized.•Di-n‑butyl and triphenyltin(IV) Schiff base carboxylates present higher in vitro cytotoxicities against four cisplatin-resistent cancer cell lines than the dimethyl derivative.•Di-n-butyltin(IV) Schiff base carboxylate presents a promising drug lead for anticancer treatment through producing ROS to induce the death of cancer cells.
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关键词
Organotin(IV),Schiff base,Crystal structure,Cytotoxic activity
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