Placoisoflavones A and B, two new cytotoxic isoflavonoids from Placolobium vietnamense NDKhoi & Yakovlev
Natural product research(2024)
Abstract
Two previously unreported isoflavonoids, placoisoflavones A and B (1 and 2), along with five known compounds, calopogonium isoflavone B (3), jamaicin (4), 6-methoxycalopogonium isoflavone A (5), vestitol (6), and caviunin (7) have been isolated from the stems of Placolobium vietnamense N.D.Khoi & Yakovlev. The structures of all isolated compounds were fully characterized using spectroscopic data and comparison with the previous literature. The cytotoxicity of all isolated compounds was evaluated against HepG2 cell line, and compound 1 showed the most potent cytotoxicity with an IC50 value of 8.0 mu M.
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Key words
Cytotoxicity,Fabaceae,flavonoids,placoisoflavones A and B,Placolobium vietnamense N,D,Khoi & Yakovlev
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