Skeletal Muscle-Derived Cell Implantation for the Treatment of Fecal Incontinence: A Randomized, Placebo-Controlled Study.

Andrea Frudinger, Annett Gauruder-Burmester,Wilhelm Graf,Jan-Peter Lehmann,Ulf Gunnarsson,Minko Mihov,Peter Ihnát, Pavle Kosorok,Julius Orhalmi, Petr Slauf,Anton Emmanuel,Vladislav Hristov, Anna Jungwirthova,Paul-Antoine Lehur, Andreas Müller,Melanie Amort,Rainer Marksteiner,Marco Thurner

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association（2023）

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摘要

Injection of a high dose of autologous skeletal muscle-derived cells followed by electrical stimulation significantly improved FI, particularly in patients with limited FI duration and high IEF at baseline, and could become a valuable tool for treatment of FI, subject to confirmatory phase 3 trial(s). (ClinicalTrialRegister.eu; EudraCT Number: 2010-021463-32).

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关键词

Cell Therapy,Fecal incontinence,Myogenic Progenitor Cells,Regenerative Medicine,Skeletal Muscle–Derived Cells

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